Catalytic Poisons and Magnetic Susceptibility

A solid phase assay for topoisomerase I interfacial poisons and catalytic inhibitors.

We report a mechanism-based screening technique to rapidly identify eukaryotic topoisomerase I targeting agents. The method is based on genetic tagging of topoisomerase I to immobilize the enzyme on a solid surface in a microtiter well format. DNA is added to the wells, and retained DNA is detected by Pico Green fluorescence. Compounds that result in an increase in Pico Green staining represent...

Cholera and Fever Poisons

Cholera and Fever Poisons

sooner, especially as I have additional experiences on the subject, which I trust will prove not valueless. I regret that carelessness in punctuating should h;iva had such an effect on " Alpha", as 1 can easily see that it has caused him to have many misconceptions with regard to the matter contained in the paper. I will try and remedy some of them now, and as I suppose he has put most of his d...

synthesis of amido alkylnaphthols using nano-magnetic particles and surfactants

we used dbsa and nano-magnetic for the synthesis of amido alkylnaphtols.

Theoretical study of magnetic susceptibility and optical activity of small molecules containing one chiral center

In the first part of this work, correlation between optical activity and elements of magnetic susceptibility tensor (MST) for five classes of model small molecules containing a single chiral center has been studied using quantum computational techniques at DFT-B3LYP level of theory with 6-311G basis set. Several molecular properties are used to reduce the MST elements prior to the examination o...